The objective of this study is to provide a rheological characterization of binary hydroalcoholic gels made with Carbopol Ultrez 10 U10 and Hyaluronic Acid HA as a function of polymer concentration: U10 0. Interaction of the two polymers was measured using the Viscose Synergy Index I S and thixotropic analysis, which indicate the structural changes that take place in binary gels attributable to molecular interactions between the gelling agents. The behavior of the binary gels studied is the result of the formation of a more structured three-dimensional network between the U10 and HA molecules. Shearing of this polymer network requires application of a greater force than is needed to shear the structure of the separate gels. Inclusion of HA in a proportion of 1 : 10 has a fixing effect on the polymer network, resulting in greater resistance to shearing in the compound gel.

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Flow curves of all hydroalcoholic gels were adjusted to the Ostwald model. Sigmoidal dose response functions were obtained to describe the pH dependence of consistency index of the systems. The concentration dependence of flow indexes was best adjusted to one-phase exponential decay functions.

Finally, by substituting in the power law expression, an empirical model is given to estimate viscosities of gels for any value of pH and polymer concentration in the ranges evaluated. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features! Clipboard, Search History, and several other advanced features are temporarily unavailable. Search: Search. Advanced Clipboard. Create file Cancel. Email citation To:. Format: Summary Summary text Abstract Abstract text.

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Save Cancel. Create a file for external citation management software Create file Cancel. Full-text links Cite Favorites. Similar articles Systematic study of the flow behaviour and mechanical properties of Carbopol Ultrez 10 hydroalcoholic gels. Fresno MJ, et al. Eur J Pharm Biopharm. PMID: The influence of cosolvent polarity on the flow properties of hydroalcoholic gels: empirical models. Chem Pharm Bull Tokyo. Fresno Contreras MJ, et al. Sanz Taberner T, et al.

Int J Pharm. Evaluation of carbopol hydrogels with lidocaine]. Ceska Slov Farm. PMID: Review. Show more similar articles See all similar articles. Cited by 1 article Rheological characterization of topical carbomer gels neutralized to different pH. Islam MT, et al. Pharm Res. Publication types Research Support, Non-U. Gov't Actions. Algorithms Actions. Drug Carriers Actions.

Hydrogen-Ion Concentration Actions. Rheology Actions. Viscosity Actions. Substances Acrylic Resins Actions. Gels Actions. Polyvinyls Actions. Ethanol Actions. Full-text links [x] Elsevier Science. Copy Download.


Rheological Study of Binary Gels With Carbopol Ultrez 10 and Hyaluronic Acid

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Carbopol® Ultrez 10 polymer



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