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Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system. Brain Behav Immun ; , Oct. Multiple sclerosis MS is a progressive T cell -mediated autoimmune demyelinating inflammatory disease of the central nervous system CNS. Although it is recognized that cognitive deficits represent a manifestation of the disease , the underlying pathogenic mechanisms remain unknown.

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Spatial reference memory deficits precede motor dysfunction in an experimental autoimmune encephalomyelitis model: the role of kallikrein-kinin system. Brain Behav Immun ; , Oct. Multiple sclerosis MS is a progressive T cell -mediated autoimmune demyelinating inflammatory disease of the central nervous system CNS. Although it is recognized that cognitive deficits represent a manifestation of the disease , the underlying pathogenic mechanisms remain unknown. Here we provide evidence of spatial reference memory impairments during the pre-motor phase of experimental autoimmune encephalomyelitis EAE in mice.

Specifically, these cognitive deficits were accompanied by down-regulation of choline acetyltransferase ChAT mRNA expression on day 5 and 11 post- immunization , and up-regulation of inflammatory cytokines in the hippocampus and prefrontal cortex. Moreover, a marked increase in B1R mRNA expression occurred selectively in the hippocampus , whereas protein level was up-regulated in both brain areas. The discovery of kinin receptors, mainly B1R, as a target for controlling neuroinflammatory response, as well as the cognitive deficits induced by EAE may foster the therapeutic exploitation of the kallikrein-kinin system KKS , in particular for the treatment of autoimmune disorders, such as MS, mainly during pre-symptomatic phase.

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Di Gesu, Giovanni M. No Brasil, predomina o desencadeamento por medicamentos, seguido de alimentos e de insetos 8 C. Como se caracterizam os quadros de anafilaxia fatal? Como investigar a causa da anafilaxia? Conflito de interesses. Rev Bras Alerg Imunopatol ; The diagnosis and management of anaphylaxis practice parameter: update.

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CALICREINA CININA PDF

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